NIH-NRSA Fellow, 2010-2013, New York University, New York, NY
Ph.D. 2009, Purdue University, West Lafayette, IN
M.S. 2002, University of Florida, Gainesville, FL
B.S. 2000, Lipscomb University, Nashville, TN
IB 100 Biological Sciences (online, Spring semester)
Integrating genomics and metabolomics to investigate the regulatory cross-talk between primary and secondary metabolism.
Current climate models predict that increases in global surface temperatures will result in climate extremes and increased incidence and intensity of droughts and floods. Plants and climate change are intimately connected, thus these intensified abiotic stresses pose immediate challenges to plant growth and development. Extreme climate changes can also significantly affect nutrient and water use efficiency, as soil temperature and moisture are key determining factors for nutrient availability to plants via the soil solution.
Plant genetic diversity can provide valuable traits for meeting challenges of the future, such as adapting our crops to changes in i) climatic conditions by enhancing genes involved in secondary metabolic stress response pathways, and ii) nutrient availability by enhancing genes involved in primary metabolic nutrient uptake and assimilation pathways. Successful breeding of crops to overcome such challenges will involve detailed understanding of how primary and secondary metabolic pathways are regulated. Thus, the ambition of my lab is to investigate the molecular interface between primary and secondary metabolism using metabolomic, genomic and epigenomic approaches. I use these systems biology approaches to identifying regulatory factors that influence how a plant partitions cellular resources between primary and secondary metabolic pathways in response to environmental signals.
Para, A*, Li, Y*, Marshall-Colon, A*, Varala, K*, Francoeur, NJ, Moran, TM, Edwards, M, Hackley, C, Bargmann, BOR, Birnbaum, KD, McCombie, RW, Krouk, G, and Coruzzi, GM. 2014. Hit-and-run" transcriptional control by bZIP1 mediates rapid nutrient signaling in Arabidopsis. PNAS. EE 2014-04657R. *Equal contribution.
Krouk, G, Lingeman, J, Marshall-Colon, A, Coruzzi, G, and Shasha, D. 2013. Gene regulatory networks in plants: Learning causality from time and perturbation. Genome Biology, 14: 123.
Bargmann, B., Marshall-Colon, A., Efroni, I., Ruffel, S., Birnbaum, K., Coruzzi, G., and Krouk, G. 2013. TARGET, a transient transformation system for genome-wide transcription factor target discovery. Molecular Plant, 6:978-980.
Marshall-Colón, A., Sengupta, N., Rhodes, D. and Morgan, J.A. 2014. Simulating labeling to estimate kinetic parameters for flux control analysis. In "Plant Metabolic Flux Analysis," A. Alonso and M. Duide-Noubani Eds. Springer, NY. pp. 211-222.
Marshall-Colón, A.*, Sengupta, N.*, Rhodes, D., Dudareva, N., and Morgan, J.A. 2010. A kinetic model describes metabolic response to perturbations and distribution of flux control in the benzenoid network of Petunia hybrida. Plant Journal 62: 64-76. *Equal contribution.
Marshall-Colón, A.J., Morgan, J.A., Dudareva, N., and Rhodes, D. Application of Dynamic Flux Analysis in Plant Metabolic Networks. In "Plant Metabolic Networks," J. Schwender Ed. Springer, NY, 2009, pp. 285-305.
Orlova, I.*, Marshall-Colón, A.*, Schnepp, J., Wood, B., Varbanova, M., Fridman, E., Blakeslee, J., Peer, W.A., Murphy, A., Rhodes, D., Pichersky, E., Dudareva, N. 2006. Reduced synthesis of benzylbenzoate in petunia flowers increases contribution from the non-?-oxidative pathway to benzenoid compounds. Plant Cell 18(12): 3458-3475. *Equal contribution.