School of
Integrative Biology
James B. Nardi

315 Morrill Hall
Office: 217-333-6590

Mail: 320 Morrill Hall, 505 S. Goodwin Ave, Urbana, IL 61801

James B. Nardi
Research Scientist - Entomology


B.S., 1970, Purdue University
Ph.D., 1975, Harvard University

Development of insect stem cells

Jim Nardi's research focuses on the cell-cell and cell-substratum interactions that mold insect tissues and the insect immune response. He addresses questions at the tissue, cell, and molecular levels about factors involved in organizing insect cells into their precise patterns in space and time. These questions have focused on how cell surface and extracellular matrix molecules mediate directional movements and rearrangement of cells during development of insect tissues and during the immune response.

Representative Publications

Nardi, J. B. 1981. Induction of invagination in insect epithelium: A paradigm for embryonic invagination. Science 214, 564-566.

Nardi, J. B. 1983. Neuronal pathfinding in developing wings of the moth Manduca sexta. Developmental Biology 95, 163-174.

Nardi, J. B. and S. M. Magee-Adams 1986. Formation of scale spacing patterns in a moth wing. I. Epithelial feet may mediate cell rearrangement. Developmental Biology 116, 278-290.

Nardi, J. B. 1990. Expression of a surface epitope on cells that link branches in the tracheal network of Manduca sexta. Development 110, 681-688.

Nardi, J. B. 1993. Modulated expression of a surface epitope on migrating germ cells of Manduca sexta embryos. Development 118, 967-975.

Nardi, J. B. and E. G. Cattani 1995. Expression of a cell surface protein during morphogenesis of the reproductive system in Manduca sexta embryos. Both moths and mammals have an indifferent stage of genital differentiation. Roux Archives of Developmental Biology 205, 21-30.

Nardi, J. B., P. F. Dowd, and R. J. Bartelt 1996. Fine structure of cells specialized for secretion of aggregation pheromone in a nitidulid beetle Carpophilus freemani (Coleoptera: Nitidulidae). Tissue & Cell 28, 43-52.

Nardi, J. B., R. Martos, K.K.O. Walden, D.J. Lampe, and H.M. Robertson 1999. Expression of lacunin, a large multidomain extracellular matrix protein, accompanies morphogenesis of epithelial monolayers in Manduca sexta. Insect Biochemistry & Molecular Biology 29, 883-897.

Nardi, J. B., R.I. Mackie, and J.O. Dawson 2002. Do microbial symbionts of terrestrial arthropod guts make a significant contribution to the global nitrogen cycle? Journal of Insect Physiology 48, 751-763.

Nardi, J. B., B. Pilas, E. Ujhelyi, K. Garsha, and M.R. Kanost 2003. Hematopoietic organs of Manduca sexta and hemocyte lineages. Development Genes & Evolution 213, 477-491.

Nardi, J. B., C .M. Bee, L.A. Miller, N.H. Nguyen, S.O. Suh, M. Blackwell 2005. Communities of microbes that inhabit the changing hindgut landscape of a subsocial beetle. Arthropod Structure & Development 35, 57-68 .

Nardi, J.B. 2007. Life in the Soil. A Guide for Naturalists and Gardeners. University of Chicago Press.

Nardi, J.B., L.A. Miller, C.M. Bee, R.E. Lee, and D.L. Denlinger 2009. The larval alimentary canal of the Antarctic insect, Belgica antarctica. Arthropod Structure & Development 38, 377-389.

Nardi, J.B., C. M. Bee, C.M, and L. A. Miller 2010. Stem cells of the beetle midgut epithelium. Journal of Insect Physiology 56, 296-303.

Nardi, J.B., C. M. Bee, L.A. Miller, D. Mathur, and B. Ohlstein 2011. Cell renewal in adjoining intestinal and tracheal epithelia of Manduca. Journal of Insect Physiology 57, 487-493.

Nardi, J.B. and C.M. Bee 2012. Regenerative cells and the architecture of beetle midgut epithelia. Journal of Morphology 273, 1010-1020.